ocyanate. A 1% solution of MDI (reagent grade) in ethyl acetate was applied to a group of 79 7-week-old male mice. MDI did not show toxicities to fish, aquatic invertebrates, algae, or microorganisms under any acute or long-term exposure testing conditions. Estos estudios parecen indicar que la MDA hidrolizable cida del plasma puede ser un biomarcador til de la exposicin prolongada al MDI. MDI is not acutely toxic to laboratory mammals. The main effect of the isocyanate group (-NCO) on reactivity is in the 2 and 4 positions. An example of a guidance value calculation is given in the US EPAs Integrated Risk Information System (IRIS) (see www.epa.gov/iris for details). Lushniak et al. 0 642643. Specific IgG and IgE antibodies to MDIHSA conjugates were present in all subjects. MDI is not stable in DMSO, there being many products generated within minutes (Herbold, 1990a,b; Gahlmann, 1993). Structural reaction injection molding (RIM) materials. The health end-points of most concern are occupationally induced asthma, hypersensitivity pneumonitis, and inflammatory upper respiratory tract diseases through inhalation of polymeric or monomeric MDI. If no opinions contrary to the provisional OEL are filed with the Committee, it is adopted as the formal OEL recommended by JSOH. A 2-year chronic toxicity/carcinogenicity inhalation study was carried out with SPF Wistar rats (60 per sex per exposure level) exposed whole body to PMDI aerosol at 0, 0.19, 0.98, or 6.03 mg/m3 for 6 h per day, 5 days per week (Reuzel et al., 1994b). MDA concentrations formed in the environment by the reaction of MDI with water are always low. The rats were exposed for 6 h/day, 5 days/week, for 24 mo to nominal exposure levels of 0, 0.2, 1.0, and 6.0 mg/cu.m. Gravid Wistar rats were exposed by whole-body inhalation to clean air (control) and to monomeric 4,4-MDI at 1, 3, or 9 mg/m3 for 6 h per day from day 6 to day 15 post-conception (Buschmann et al., 1996). Molecular Formula CHNO. Le MDI polymris (PMDI), qui est la forme technique et commerciale principale de ce compos est en fait un mlange contenant 25 80 % de 4,4-MDI monomre et des oligomres 3-6 cycles plus quelques isomres comme lisomre 2,2. On the other hand, the much less reactive aromatic amines, as the methylene-bis-ortho-chloroaniline (MOCA) are used as chain extenders for casting elastomers (Chapter 6). Some body weight depression was observed in males of the mid-concentration group through week 10. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. 4 European Union's Annex VI to Regulation (EC) No 1272/2008, updated by the 1st Adaption to Technical Progress to the Regulation. 4,4'-MDI can be obtained by purifying the diphenylmethane diisocyanate mixture. The composition of PMDI varies with the manufacturer and use. The pure material methylene diphenyl-isocyanate is a solid that melts around 37C. The non-neoplastic information in this study suggests a NOAEL of 0.19 mg/m3 and a lowest-observed-adverse-effect level (LOAEL) of 0.98 mg/m3. MDI polymerized to inert polyurea and stayed on top of the sediment, forming a hardened layer at the interface of the compound and water. Iran J Chem Chem Eng 40(4):12561268, Al-Moameri HH et al (2020) Impact of nanoparticles on polyurethane resins final properties. There are no data available for oral exposure, but it is unlikely that humans are exposed to MDI by the oral route. Lecture, University of Bielefeld, Bielefeld, June (unpublished report). It has a boiling point of >300 C at 101.3 kPa, a melting point of 3943 C, and a vapour pressure of <1 mPa at 20 C. No desquamation or fissuring was noted with the compound. Treatment did not influence any other maternal or fetal parameters investigated, although a slight but significant increase in litters with fetuses displaying asymmetric sternebra was observed after treatment with the highest dose. Mobile parts of the macrobenthos (e.g., Gastropoda) remained unaffected. Herbold B (1980a) [MDI Salmonella/microsome test for investigation of point mutation activity.] These effects correlated with pulmonary function deficits (FEF25 [forced expiratory flow from 25% of the forced vital capacity, or FVC] and carbon monoxide diffusion), particularly in the high-exposure group. Complex mixtures of airborne isocyanates and related compounds formed during the thermal decomposition of polyurethane were analysed by derivatization of isocyanates in impinger flasks containing dibutylamine with formation of urea derivatives. From day 6 to day 9 of pregnancy, maternal body weight gain of the 8 and 12 mg/m3 groups was slightly decreased (not statistically significant) when compared with the control group. 13674-84-5 Tris(2-chloro-1-methylethyl) phosphate 1500 mg/kg Rat >5000 mg/kg Rabbit N.I. No treatment-related findings in dams and fetuses occurred at 1 and 4 mg/m3. NIOSH (1985) NIOSH manual of analytical methods, 3rd ed. Responsible authorities are strongly encouraged to characterize risk on the basis of locally measured or predicted exposure scenarios. These conditions will also form MDA from conjugated MDI. Correspondence to Moins de 1 % de la radioactivit a t rcupr dans les principaux organes, mais 23 % de la dose initiale ont t retrouvs dans la carcasse. Prog Polym Sci 26(5):799851, Article Toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI) are highly reactive materials used on a large scale in the production of polyurethanes. Le PMDI sert la confection de mousses rigides ou souples, de liants pour sable de moulage et disolants thermiques. The mean number of corpora lutea, implantation sites, early and late resorptions, and, consequently, pre- and post-implantation loss showed no statistically significant differences among the control and treated groups. There is clear evidence of skin sensitization due to MDI. Methylene diphenyl diisocyanate, 4,4'- (50C, molten) 101-68-8 . However, when guinea-pigs were exposed to a high concentration of 4,4-methylenediphenyl diisocyanate (135 or 360 mg/m3 . It has a boiling point of >300 C at 101.3 kPa, a melting point of 3943 C (capillary method) or 40 C (differential scanning calorimetry or DSC method) (Kelly et al., 1997), and a vapour pressure of <1 mPa at 20 C (DFG, 1997). In an epidemiological study of occupational dermatitis in five different shoe factories, 246 workers were interviewed, examined, and patch-tested using standard and occupational patch-test procedures of the International Contact Dermatitis Research Group (Mancuso et al., 1996). Comments were received from: M. Baril, Institut de Recherche en Sant et en Scurit du Travail du Qubec, Canada, T. Berzins, National Chemicals Inspectorate (KEMI), Sweden, R. Cary, Health and Safety Executive, United Kingdom, Chemical Industries Association (CIA) Isocyanate Producers Sector Group (IPSG), United Kingdom, M. Collins, Gilbert International Limited, United Kingdom, P. Edwards, Department of Health, United Kingdom, T. Fortoul, National University of Mexico, Mexico, R. Hertel, Bundesinstitut fr Gesundheitlichen Verbraucherschutz und Veterinrmedizin, Germany, J. Lesage, Institut de Recherche en Sant et en Scurit du Travail du Qubec, Canada, H. Nagy, National Institute for Occupational Safety and Health, Cincinnati, USA, D. Willcocks, National Industrial Chemicals Notification and Assessment Scheme, Australia, P. Yao, Chinese Academy of Preventive Medicine, Peoples Republic of China, K. Ziegler-Skylakakis, GSF-Forschungszentrum fr Umwelt und Gesundheit GmbH, Germany, Mr H. Abadin, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA, Dr B. kesson, Department of Occupational & Environmental Health, University Hospital, Lund, Sweden, Dr T. Berzins (Chairperson), National Chemicals Inspectorate (KEMI), Solna, Sweden, Mr R. Cary, Health and Safety Executive, Bootle, Merseyside, United Kingdom, Dr R.S. If you want to reproduce the whole article Sa tension de vapeur est infrieure 1 mPa 20 C. Board members, authors, reviewers, consultants, and advisers who participate in the preparation of a CICAD are required to declare any real or potential conflict of interest in relation to the subjects under discussion at any stage of the process. IPCS (1993) International Chemical Safety Card Methylene bisphenyl isocyanate (MDI). Seel K, Walber U, Herbold B, Kopp R (1999) Chemical behaviour of seven aromatic diisocyanates (toluenediisocyanates and diphenylmethanediisocyanates) under in vitro conditions in relationship to their results in the Salmonella/microsome test. Con respecto a la exposicin por inhalacin, solamente se dispone de estudios limitados en ratas. Tarlo SM, Liss GM, Dias C, Banks DE (1997) Assessment of the relationship between isocyanate exposure levels and occupational asthma. It was insoluble in water and found to be not inherently biodegradable (Yakabe et al., 1994). Kelly M, Outterside S, Pemberton D (1997) Physical properties of MDI and TDI: a review. Basal cell hyperplasia in the olfactory epithelium was elevated significantly in males only at the mid and high concentrations. May cause an allergic skin reaction. Whether there was exposure to other substances that could cause asthma or whether there was pre-existing asthma was not reported, and guidelines followed for performing FEV1 measurements were not stated. Le MDI ne prsente aucune toxicit pour les poissons, les invertbrs aquatiques, les algues ou les microorganismes dans des conditions dexposition susceptibles de gnrer une intoxication aigu ou chronique. (1990, 1994a) data set. When rats were exposed to PMDI aerosol (in which more than 99% of particles were smaller than 5 m) for 4 h at concentrations of 384, 418, 500, or 523 mg/m3, animals sat quietly with closed eyes during exposure, and their breathing became laboured and nostrils dilated, especially in the highest concentration group (Appelman & de Jong, 1982). Effects on lung function were assessed by DFG (1997) based on the results of nine studies namely, Cavelier et al. l[Ipb*GY+g1hYNIN c/-"a7BYE93R;( `PyQ2/xeI )PxrZT@ChaAT Rjt !@@e*9s)g JTc:PPk @f7NwE@ endstream endobj 20 1 obj 264 endobj 21 1 obj << /Type /Page /Parent 32 0 R /Resources << /ColorSpace << /CS20 14 2 R /CS21 17 2 R /CS18 14 2 R /CS19 17 2 R /CS16 14 2 R /CS17 17 2 R /CS14 14 2 R /CS15 17 2 R /CS12 14 2 R /CS13 17 2 R /CS10 14 2 R /CS11 17 2 R /CS8 14 2 R /CS9 17 2 R /CS6 14 2 R /CS7 17 2 R /CS4 14 2 R /CS5 17 2 R /CS2 14 2 R /CS3 17 2 R /CS0 14 2 R /CS1 17 2 R >> /Font << /TT20 10 0 R /TT21 8 0 R >> /ExtGState << /GS10 13 3 R >> /ProcSet [ /PDF /Text ] >> /Contents 271 0 R >> endobj 24 1 obj << /Type /Page /Parent 32 0 R /Resources << /Font << /F0 8 0 R /F1 10 0 R /F2 27 0 R >> /ProcSet 5 1 R >> /Contents 25 1 R >> endobj 25 1 obj << /Length 26 1 R /Filter /LZWDecode >> stream 11 Isocyanates react with water to form amines. The Committee submits the OEL as a provisional OEL to a meeting of JSOH councillors and to an annual general meeting of JSOH for temporary approval, after which the provisional OEL and documentation are published in JSOHs official journal, Sangyo Eiseigaku Zasshi (formerly Sangyo Igaku [Japanese Journal of Industrial Health]. Appelman LM, de Jong AWJ (1982) Acute inhalation toxicity study of polymeric MDI in rats. The literature up to November 1998 was searched using MEDLINE to identify any new information relevant to the assessment. MDI concentrations in the working environment were shown to significantly influence lung function. Vols. In the case of diisocyanates, the reactivity of the isocyanate (N=C=O, or NCO) functional group toward water and biological (macro)molecules and the resulting reaction products are key. TNO International Isocyanate Institute (Report No.11156). Such reactions in the absence of solvents often occur with explosive violence . It is therefore concluded that the positive results obtained with diisocyanates in DMSO solutions are due to the formation of MDA. van der Hoeven N, Roza P, Henzen L (1992a) Determination of the effect of TDI, TDA, MDI, and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline No. Wuppeltal, Bayer AG, Institute for Toxicology. Monomeric 4,4-MDI is a white to pale yellow solid at room temperature, with a molecular weight of 250.26. The CICAD Final Review Board has several important functions: to ensure that each CICAD has been subjected to an appropriate and thorough peer review; to verify that the peer reviewers comments have been addressed appropriately; to provide guidance to those responsible for the preparation of CICADs on how to resolve any remaining issues if, in the opinion of the Board, the author has not adequately addressed all comments of the reviewers; and. 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