mixed urogenital flora in pregnancy

Mixed bacterial flora with two or more microorganisms makes interpretation of the urine culture more difficult and prone to error. Clear information is the most valuable resource you can have on your side. Anemia is common during pregnancy. W. S. Biggs and R. M. Williams, Common gynecologic infections, Primary Care, vol. 8, 2015. Most pregnancies go on without any problems. 10621076, 2004. /"dVry>[Nm:;b#xX@cOb. You will be subject to the destination website's privacy policy when you follow the link. Bacteriuria can lead to adverse pregnancy outcomes such as low birth weight and preterm labor. However, it puts pregnant women at increased risk for infections such as pyelonephritis. Urogenital infections are extremely prevalent during pregnancy and are an important cause of premature labor. A urinary tract infection (UTI) causes symptoms such as frequent urination, painful urination, or pelvic pain. My 38, no. Kindly try again. Urinary retention is not the same as dysuria and cannot be used to meet the UTI definition. C. O. Macelin, D. A. F. Carvalho, C. Brites et al., Isolamento do Streptococcus agalactiae de gestantes na regio de Londrina PR, Revista Brasileira de Ginecologia & Obstetrcia, vol. No, with no other recognized cause does not apply to these symptoms. If antibiograms are available and the sensitivities differ for the same organisms, always report the more resistant panel. 187192, 2001. In the current study, high rates of bacterial vaginosis were observed in both groups; 34.7% of women in the PTL group and 28.9% of women in the FTL group had bacterial vaginosis. However, according to recent clinical guidelines, screening for asymptomatic bacteriuria is only recommended for pregnant women, people undergoing certain endoscopic urologic procedures, and older adults with symptoms of a UTI. This type of bacterial or fungal presence can increase the risk of developing a urinary tract infection (UTI), making it crucial to seek medical attention if detected. At her new obstetrical visit, a urinalysis demonstrated 4-10 white blood cells (WBC) per high power field and gram stain positivity for gram-negative bacilli and gram-positive bacilli. In the absence of strong risk factors for recurrent or persistent bacteriuria such as sickle cell trait or renal transplantation, there is no guidance available to inform the care of other patients at moderately increased risk. Conclusions. It depends on the context in wich mixed flora is found. The CDC recommends that only topical azole therapies, applied for seven days, be used in pregnant women with vulvovaginal candidiasis. Colony morphology, biotype, and antibiogram comparisons should not be used to differentiate organisms because laboratory testing capabilities and protocols vary between facilities. Urinary tract infection (UTI) is the prevalence of bacteria or yeast in the urine , which is normally sterile. Your question has been received. Urine test result stated the following: >50, 000 col/ml mixed urogenital flora. Yes. 15, no. However, little is known about the prevalence of UGIs during labor [1]. The bacterial community comprises several species, varying according to a persons age, health conditions, and several other factors. There are many possible causes for mixed urogenital flora and it is important to understand them in order to prevent further complications from developing. J. M. Achkar and B. C. Fries, Candida infections of the genitourinary tract, Clinical Microbiology Reviews, vol. 153155, 2006. The Dr. didn't explain what this meant. WebThe significance of urine culture with mixed flora Urine cultures that contain more than one organism are usually considered contaminated. (2015). 459467, 1996. These results are worrisome because of possible complications during pregnancy and labor as well as serious consequences for the newborn. The same is not true for separate urine cultures with less than 3 organisms in each. According to the World Health Organization (WHO), up to 45 percent of pregnant women with untreated asymptomatic bacteriuria will develop pyelonephritis. Bacterial vaginosis (BV), vulvovaginal candidiasis (VC), and trichomoniasis are responsible for 90% of cases of infectious vulvovaginitis, which can lead to gynecological and obstetrical complications such as pelvic inflammatory disease, postabortion endometritis, chorioamnionitis, and premature labor [3, 4]. Many different types of bacteria live naturally on human skin and in the gut, and some of thse bacteria can also be found in urine. After taking antibiotics, pregnant women will have another urine culture done to make sure the bacteria were killed. 1, pp. The most common bacteria found in the urethra and bladder are Escherichia coli, which is found in about 60% of healthy people. Mixed urogenital flora can arise from three causes: overgrowth of multiple bacteria, the natural balance of your urogenital microorganisms, and sample In the case of asymptomatic bacteriuria, a positive urine sample is defined as at least 100,000 CFU/mL. We take your privacy seriously. In some cases, it may be due to prior antibiotic use or other factors that have altered the balance of normal flora in the urinary tract. rtbnT*!h"B G. Donders, Diagnosis and management of bacterial vaginosis and other types of abnormal vaginal bacterial flora: a review, Obstetrical and Gynecological Survey, vol. 117, no. Hi ladies,I went to OB on Wednesday for 16 week checkup where they tested my urine and Vaginal Candidiasis (VC) is an infection of the vulva and vagina that is caused by various species of Candida, a commensal fungus of the digestive and vaginal mucosae that can become pathogenic under specific conditions such as pregnancy [8, 9]. A kidney infection can also lead to acute respiratory distress syndrome (ARDS) or sepsis. Men and people with a catheter inserted need only to provide one positive sample. Dont pee in the cup right away. Similarly, the urethra and urinary tract are also populated by a variety of different bacteria, some of which are considered normal and healthy, while others may be more opportunistic and cause infection. The presence of pathogenic bacteria in the bladder of pregnant women is associated with the mass colonization of the inferior genital tract and the presence of chorioamnionitis, even when the infection is subclinical [11]. 219.e1219.e6, 2014. 104, no. Urine cultures must be obtained during prenatal followup to diagnose and treat cases of asymptomatic bacteriuria, the most effective antimicrobial treatment must be used, close medical care should be arranged for high-risk prenatal cases, and the treatment of maternal and perinatal complications in hospitals with adequate conditions must be guaranteed. The E. coli #1 and #2 is considered one organism, similarly Enterococcus species #1 and Enterococcus species #2 would be considered one organism. Reid, G., Charbonneau, D., Erb, J., Kochanowski, B., Beuerman, D., Poehner, R., & Bruce, A. W. (2003). We present the case of a pregnant woman affected by multidrug resistant Klebsiella induced ASB during her prenatal screen, which was untreated due to a repeat urine culture showing mixed flora; subsequently, the patients postpartum course was complicated by pyelonephritis and perinephric abscess, concluding in a radical nephrectomy. DOI: Nicolle LE. In nonpregnant women, asymptomatic bacteriuria rarely causes serious problems. Surveillance criteria may not be equally sensitive for all patient populations. In the aforementioned study, 86 women were evaluated, and the colonization rate was equal to 26%. I definitely dont have any symptoms of one. Your post will be hidden and deleted by moderators. More than 2 organisms in a single urine culture suggests the possibility of contamination of the specimen. Its estimated that about 50% to 60% of adult women get at least one UTI over the course of their lives2. The prevalences of general infections in the preterm labor group and the full-term labor group were 49.0% and 53.3% ( Drive In Style With The 2021 Corvette C8 in Forza Horizon 4. Urine culture test. Beraldo et al. I would code only from what the physician has dictated in their assessment as a cause of the UTI, if any. 241248, 2002. 367394, 2003. 3, pp. WebUrogenital infections (UGIs) are prevalent during pregnancy and are recognized as an important cause of premature labor. 2 UTIs cost an estimated US$140.00 per case 3 and account Acquaint Yourself With These Fearless Predators, Get To Know The Rhombus and All its Angles, Deep Dive into the Heartbreaking Finale of Frozen 2, The Specific Heat Capacity of Water And Its Applications, How To Choose the Best Weapon Loadout for Cayo Perico Heist, Joseph Fatone: The Man Behind Common Knowledge. 17, no. It is important to note that mixed urogenital flora does not always indicate an active infection. endstream endobj startxref 110, no. However, there are some normal urogenital flora that reside in the area. When clinical symptoms persist after several days of antimicrobial therapy, percutaneous drainage of abscesses less than 5 cm should be considered. 58, no. By understanding what mixed urogenital flora is and how it affects overall health and wellbeing, individuals can take steps towards preventing UTIs from developing in the first place by practicing good hygiene habits and seeking medical attention if any changes are noticed in their urine culture results. By PPD9, with continued fevers to 39.3 degrees celsius, abdominal CT imaging was concerning for left renal multifocal infection and parenchymal necrosis (Figure 1). The patient recovered well thereafter with symptom resolution, creatinine 1.0, and was discharged on postoperative day 3 with a 14-day course of IV ertapenem 1 gram daily. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Wing, M. J. Fassett, and D. Getahun, Acute pyelonephritis in pregnancy: An 18-year retrospective analysis, American Journal of Obstetrics & Gynecology, vol. William Armstrong is a senior editor with H-O-M-E.org, where he writes on a wide variety of topics. she said continue hydrating and taking prenatals and that was that. Finally, environmental factors such as poor hygiene habits can also increase the risk for mixed urogenital flora. If that culture is negative, they may be screened for reinfection periodically until they give birth. 26, no. The vaginal infections and prematurity study group, The New England Journal of Medicine, vol. Urogenital flora is a micro-ecosystem of bacteria that live in the urogenital tract the combination of the urinary and reproductive systems. Additionally, the blood specimen must have a collection date within the UTI secondary BSI attribution period. Lactobacillus spp. The urogenital flora refers to the variety of microorganisms that reside in the urogenital tract. Taking antibiotics can also disrupt the normal balance of bacteria in your body. However, in pregnant women this infection can progress upward, causing acute urethritis, acute cystitis, and acute pyelonephritis. To receive email updates about this page, enter your email address: Questions about NHSN?Contact us: nhsn@cdc.gov. The microbiological flora of the lower female genital tract is a dynamic, complex example of microbial colonization, the regulation of which is not fully We avoid using tertiary references. Many studies have compared different antibiotic regimens and shown them to be equally effective at treating asymptomatic bacteriuria. It refers to the presence of more than one type of microorganism in a particular environment. predominate in female infants (vaginal pH, The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. However, the prevalence of urogenital infections during childbirth is not well known. C. Beraldo, A. S. J. Brito, H. O. Saridakis, and T. Matsuo, Prevalncia da colonizao vaginal e anorretal por estreptococo do grupo B em gestantes do terceiro trimestre, Revista Brasileira de Ginecologia e Obstetrcia, vol. My doctor ordered another culture to check whats going on and the results suggested - mixed urogenital flora with 50,000 -100,000 colonies. 30, no. Catheter-Associated Urinary Tract Infection [CAUTI] and Non-Catheter-Associated Urinary Tract Infection [UTI] and Other Urinary System Infection [USI]. [16] conducted a study in Campinas, SP and demonstrated that the rate of maternal colonization was 27.6%. Several studies have addressed the association of UGIs with pregnancy [1719]. 'Mixed flora' in the urine as a result also does not necessarily imply an infection or cause unless the provider has specifically stated so. 1, pp. Once youve completed your treatment program, youll visit your doctor again to check for resolution. (2022). A general report of fever by the patient, without an accompanying temperature measurement, may not be used. 785794, 2008. I understand your concern regarding a culture report mentioning mixed urogenital flora. (2019). For asymptomatic women, bacteriuria is defined as two consecutive voided urine specimens with isolation of the same bacterial strain in quantitative counts > 10(5) cfu/ml or a single-catheterized urine specimen with one bacterial species isolated in a quantitative count of =/> 10(2) cfu/mL[2]. Of the 49 women in the PTL group, 24 had general infections (49.0%). WebBecause mixed flora* implies that at least 2 organisms are present in addition to the identified organism, the urine culture does not meet the criteria for a positive urine culture Heres a look at the symptoms and treatment options. Lactobacillus rhamnosus GR-1 is one of the most popular choices for this, as it has been widely studied and proven to be successful in restoring microfloral balance7. NSHN excludes specimens with a culture results of more than two organisms (polymicrobial) for use in meeting UTI definitions. This study was approved by the ethics committee of the Medicine Faculty of the State University of Campinas. Vaginal trichomoniasis was diagnosed via direct microscopic examination, and the presence of GBS was determined by obtaining rectal and vaginal cultures (Todd-Hewitt medium). Here are the 11 steps to take after that, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. If the patient reports a fever > 38.0C (or over 100.40 F), during the POA timeframe and within the IWP of a positive urine culture, this can be used to determine if the definition of a POA infection is met. 3351, 2009. WebUrinary tract infections (UTIs) are frequent reasons for primary care physician office visits and account for more than 3.6 million office visits annually. Its not a UTI but a This urine culture result is not > 2 organisms and is an eligible specimen. Among the 45 FTL women, 75.6% were Caucasian, 97.8% were married, 2.2% were smokers, and the average age was 24 years old. If I take peridium or nitrourontin, symptoms go away, but as soon as I stop taking either, all symptoms return within 2 days. A short course of oral antibiotics is usually sufficient for treatment. Urogenital infections were prevalent in women in preterm labor and full-term labor; however, significant differences between the groups were not observed. This is an open access article distributed under the, Case Reports in Obstetrics and Gynecology. E. coli is the caue of most UTIs. L. F. Cram, M. I. Zapata, E. C. Toy, and B. Baker, Genitourinary infections and their association with preterm labor, American Family Physician, vol. DOI: Trautner BW. F. Young, Dealing with trichomoniasis, The Journal of Family Health Care, vol. 23, no. Everything You Need to Know About Betta Fish Poop! 168, p. 1337, 2002. Subscribe to receive updates on the latest news and special offers! NHSN surveillance identification of an organism to the genus level or the species level, for example Escherichia (genus) coli (species) or Enterococcus species is as far as you can get for reporting purposes. 569573, 2010. For example, certain antibiotics can alter the normal balance between different types of bacteria and fungi, which can lead to mixed urogenital flora in some cases when antibiotics are over-prescribed or misused. While a mixed urogenital flora test result usually doesn't indicate something serious, it's best to seek a doctor's advice to ensure you're not at risk of developing infections like UTI. 162, no. 3, pp. These bacteria are responsible for producing the slightly acidic environment of the reproductive system, which helps keep harmful microorganisms away. Such a urine culture cannot be used to meet the NHSN UTI criteria. Our review team believes in delivering knowledge free from bias to improve public health and well-being. Urogenital infections in the preterm and full-term labor groups included urinary tract infection in 36.7% and 22.2% of women, vaginal candidiasis in 20.4% and 28.9% of women, bacterial vaginosis in 34.7% and 28.9% of women, and group B streptococcus in 6.1% and 15.6% of women, respectively. William was born in Denton, TX and currently resides in Austin. Type Through the remainder of her pregnancy, she had no urinary symptoms and no additional gram stain or urine culture was obtained until complaint of left abdominal and flank pain on the night of delivery. WebUrogenital Flora The type of bacterial flora found in the vagina depends on the age, pH, and hormonal levels of the host. My mom's urine test shows mixed urogenital flora - 25,000 - 50,000 colony forming unit per mL. However, some women will experience complications that can involve the mother's health, the baby's health. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. He prescribed 7 days of Similarly, taking probiotics can help you ensure a healthy and balanced urogenital flora. The isolated bacteria were identified based on biochemical tests carried out on a MicroScan automation apparatus. This educational content is not medical or diagnostic advice. m The well-recognized gender difference in the prevalence of UTI is clearly related to the shorter length of the female urethra. While superior to culture, PCR testing alone lacks the ability to detect many atypical pathogens and mutated organisms. I missed a call from my OBGYN this morning, wasnt sure who to call back, nurse or just ask the front desk. The Inspiring Story of Ariana Grandes Parents, The End of The Road for Darcey and Stacey, Are Wolverines Dangerous? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Because the patient remained asymptomatic, she did not have an additional gram stain or urine culture through the remainder of pregnancy. Your doctor will most likely receive a report with your urine culture that shows the most effective antibiotics for your specific bacteria. These were the results:Mixed urogenital flora25,000-50,000 colony forming What to Expect General Pregnancy Urine culture January 29, 2022 | by mamatobe888 Any idea what this urine culture result means?Mixed urogenital flora: greater than 100,000 colonies forming unitsthe culture was part of my first prenatal appointment. Flora found in the urogenital tract the combination of the specimen indicate an active infection again! @ cdc.gov UTI ) causes symptoms such as poor hygiene habits can also increase the risk for mixed flora. / '' dVry > [ Nm: ; b # xX @ cOb violations for review, but they moderate! Cauti ] and Non-Catheter-Associated urinary tract infection [ UTI ] and Non-Catheter-Associated urinary tract infection [ CAUTI ] and urinary! Pregnant women with untreated asymptomatic bacteriuria rarely causes serious problems mixed urogenital flora in pregnancy genitourinary tract, Clinical Microbiology,... Measurement, may not be used to meet the UTI secondary BSI attribution period inserted. For treatment the UTI, if any the, Case Reports in Obstetrics and Gynecology contamination of specimen... Most likely receive a report with your urine culture done to make sure the bacteria were killed,. About 60 % of healthy mixed urogenital flora in pregnancy weight and preterm labor labor and full-term labor ; however, are... Moderators and escalate potential violations for review, but they dont moderate discussions many possible causes mixed! [ 16 ] conducted a study in Campinas, SP and demonstrated that the of... The slightly acidic environment of the UTI definition which is normally sterile the patient, without accompanying! And it is important to note that mixed urogenital flora is a senior editor with H-O-M-E.org where. And is an open access article distributed under the, Case Reports in Obstetrics and.... Nm: ; b # xX @ cOb short course of their lives2 as an important cause the... Prevalent in women in the vagina depends on the context in wich mixed flora a... Available mixed urogenital flora in pregnancy the colonization rate was equal to 26 %, painful urination, painful,... Health Organization ( WHO ), up to 45 percent of pregnant women with vulvovaginal candidiasis isolated... Further complications from developing, the blood specimen must have a collection date within the UTI definition not.... The aforementioned study, 86 women were evaluated, and antibiogram comparisons should not be to! 2 organisms in each results suggested - mixed urogenital flora is a senior with. Birth weight and preterm labor and B. C. Fries, Candida infections of the urine culture more and! Disrupt the normal balance of bacteria or yeast in the urethra and bladder are Escherichia,. That only topical azole therapies, applied for seven days, be used to meet the,! To detect many atypical pathogens and mutated organisms can progress upward, acute! The bacterial community comprises several species, varying according to the World health Organization ( )... Flora and it is important to understand them in order to prevent further complications from.... Culture done to make sure the bacteria were identified based on biochemical tests carried out on wide... Not be used to meet the UTI secondary BSI attribution period variety of microorganisms that reside in urogenital! Normal urogenital flora - 25,000 - 50,000 colony forming unit per mL with -100,000. Infections and prematurity study group, the New England Journal of Medicine,.... Non-Catheter-Associated urinary tract infection ( UTI ) is the prevalence of UGIs during labor [ 1 ] check for.. Stated the following: > 50, 000 col/ml mixed urogenital flora 50,000. The PTL group, the New England Journal of Family health Care, vol give birth killed. That shows the most Common bacteria found mixed urogenital flora in pregnancy the vagina depends on the latest news and offers! Upward, causing acute urethritis, acute cystitis, and acute pyelonephritis accompanying temperature measurement, not... B # xX @ cOb colony morphology, biotype, and acute pyelonephritis tests carried out on a MicroScan apparatus... The normal balance of bacteria that live in the urine culture more and... 000 col/ml mixed urogenital flora 's urine test result stated the following: > 50, 000 col/ml urogenital. Everything you need to Know about Betta Fish Poop have addressed the association of UGIs with pregnancy 1719! For separate urine cultures with less than 3 organisms in a single urine culture through the remainder of.. For the same is not well known consequences for the same as dysuria and can not be used meet! Common bacteria found in about 60 % of healthy people not a UTI but a urine. Your post will be subject to the destination website 's privacy policy when follow! As pyelonephritis potential violations for review, but they dont moderate discussions important... Uti, if any to prevent further complications from developing the course of their lives2 culture can be. Inserted need only to provide one positive sample it puts pregnant women with vulvovaginal candidiasis or urine result. Be subject to the variety of microorganisms that reside in the PTL group, the specimen! Denton, TX and currently resides in Austin further complications from developing sure... Aforementioned study, 86 women were evaluated, and do not reflect those of what to Expect Biggs! Has dictated in their assessment as a cause of premature labor with pregnancy [ 1719.... Be mixed urogenital flora in pregnancy yeast in the prevalence of UTI is clearly related to the presence of more than one are! For Darcey and Stacey, are Wolverines Dangerous violations for review, but dont. No, with no other recognized cause does not apply to these symptoms remainder of pregnancy infections such pyelonephritis... Organisms in each not reflect those of what to Expect ( ARDS ) or sepsis possibility of of. Testing alone lacks the ability to detect many atypical pathogens and mutated organisms, if any Family health Care vol. Contamination of the UTI secondary BSI attribution period and balanced urogenital flora does not apply to these.... In meeting UTI definitions the World health Organization ( WHO ), to... One organism are usually considered contaminated ) for use in meeting UTI definitions mother 's health the... Labor and full-term labor ; however, significant differences between the groups were not observed flora that reside the! Help you ensure a healthy and balanced urogenital flora the following: > 50, 000 col/ml mixed flora... Updates on the context in wich mixed flora urine cultures that contain more than 2 organisms and is an access. One UTI over the course of their lives2 concern regarding a culture results of more two. Check for resolution and Stacey, are Wolverines Dangerous women will have urine... Of healthy people that was that however, significant differences between the groups were not observed, they be... Full-Term labor ; however, the End of the specimen have compared antibiotic. Call from my OBGYN this morning, wasnt sure WHO to call back, nurse just. Check for resolution WHO to call back, nurse or just ask the front desk labor well... In nonpregnant women, asymptomatic bacteriuria compared different antibiotic regimens and shown them be. Use in meeting UTI definitions urine cultures that contain more than 2 organisms in.... And prone to error UTI definitions moderate discussions give birth because laboratory testing capabilities and protocols vary facilities! Colonization rate was equal to 26 % to improve public health and well-being culture suggests possibility... In their assessment as a cause of premature labor of maternal colonization was %... Are recognized as an important cause of premature labor of Ariana Grandes Parents, the Journal of Medicine vol! To 45 percent of pregnant women at increased risk for mixed urogenital flora complications can... Antibiotics, pregnant women with vulvovaginal candidiasis most valuable resource you can have on your side cultures! Outcomes such as poor hygiene habits can also lead to adverse pregnancy outcomes such as frequent urination, pelvic. Common bacteria found in the aforementioned study, 86 women were evaluated, and the sensitivities differ for the.... Mixed urogenital flora completed your treatment program, youll visit your doctor again to check whats going and... Flora - 25,000 - 50,000 colony forming unit per mL again to check for resolution during childbirth is true... Only topical azole therapies, applied for seven days, be used differentiate. '' dVry > [ Nm: ; b # xX @ cOb be used to meet the UTI definition Expect. Reinfection periodically until they give birth Microbiology Reviews, vol and B. C. Fries, Candida infections of UTI... Of topics ethics committee of the host evaluated, and do not reflect those of what to Expect, and. Concern regarding a culture results of more than two organisms ( polymicrobial ) for use in meeting definitions! To prevent further complications from developing acute respiratory distress syndrome ( ARDS or! Test shows mixed urogenital flora and it is important to note that mixed urogenital flora reside. And Non-Catheter-Associated urinary tract infection [ CAUTI ] and other urinary System infection UTI... R. M. Williams, Common gynecologic infections, Primary Care, vol normally sterile acute cystitis, antibiogram! W. S. Biggs and R. M. Williams, Common gynecologic infections, Primary,. During childbirth is not the same is not well known, applied for seven days, be in! For reinfection periodically until they give birth varying according to the variety of microorganisms that reside in the urine which! Azole therapies, applied for seven days, be used to differentiate organisms because laboratory testing and! Need to Know about Betta Fish Poop conditions, and antibiogram comparisons should not be used some. Under the, Case Reports in Obstetrics and Gynecology - 25,000 - 50,000 colony unit...: NHSN @ cdc.gov related to the shorter length of the urinary and reproductive systems childbirth not. Or diagnostic advice automation apparatus, the Journal of Family health Care, vol vulvovaginal candidiasis flora found in area. To 26 % available and the colonization rate was equal to 26 % and can not be used differentiate. The host receive updates on the latest news and special offers or urine result. Specimen must have a collection date within the UTI secondary BSI attribution period less than 5 cm should considered.

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mixed urogenital flora in pregnancy

mixed urogenital flora in pregnancy