The acids anti-inflammatory, anti-bacterial, anti-keratinizing and melanin inhibiting This acid is found in some quantity in several cleaning products, detergents and bleaches. The problem with those is that its getting harder and harder to get them covered by insurance, Dr. Zampella says. Do not take azelaic acid gel by mouth. We also compiled some expert-recommended azelaic acid products in line with doctors' guidance. Its also a skin care ingredient. Overgrowth of bacteria or yeast in the pores contributes to acne. This agent has been shown to be effective in the treatment of inflammatory acne lesions, most likely as a result of keratolysis. If eye irritation lasts for a while, talk with the doctor. It might help a little bit with the pigment that's left over after an acne lesion clears, but for someone who has deeper cystic acne, [azelaic acid] isnt going to penetrate that far into the skin, Bordone says. Westbay says this serum is one of her "favorites for excessive pigmentation" thanks to its ability to tackle melasma and post-inflammatory hyperpigmentation. Heres what you need to know about treating acne or redness with azelaic acidin both its prescription and over-the-counter formulas. It is popularly known for its strong melanin inhibition properties. The rosy colour can also appear on the chest, ears and neck. Dermatology Made Easybook. The Best Way to Finally Master the Headstand, According to a Yoga Instructor. The first factor is sebum overproduction stimulated by hypersensitivity to androgenic steroids. Oh, another thing to note: Once you start using azelaic acid, its important to store it properlyat room temperature, like you would with most other skin-care products Its best to avoid extreme temperatures that could decrease the medications effectiveness, so dont put it in the fridge or freeze it, Dr. Massick says. They have been a mainstay of acne treatment for the past 25 years. Like gels, solutions work best in patients with oily skin. Salicylic acid is a less effective but more affordable alternative. Apply small amount once daily in the evening. Theres minimal fetal exposure when azelaic acid is used topically, Dr. Massick says. The combination of 5 percent benzoyl peroxide and 1 percent clindamycin in a premixed gel has also been studied. Wash your hands with soap and water. A more potent cream is GIGI Bioplasma with 15% Azelaic Acid at $34.87 (30ml). Typically, you want to either remove other irritating things from the regimen or at least separate them, so you can use one thing in the morning and another at nighttime.. The hormone is responsible for both pattern baldness and hair growth; its the reason you will see a bald man with a hairy face. Benzoyl peroxide can be obtained in various concentrations (2.5 to 10 percent), although little evidence exists that efficacy is dependent on the dose.8 This agent comes in water-based or alcohol-based gels. To minimize irritation, tretinoin should be started at a low concentration, which can then be titrated upward as needed. It helps refine skins surface to reveal a more even skin tone. Q: What is azelaic acid used for? Azelaic acid kills bacteria on your skin that causes acne. If you have not used it, worry not; we have prepared enough to let you in on what you have been missing out on. The acid has antibacterial and anti-inflammatory properties. It also strips your skin off free fatty acids on the skins lipid layer, making it bacteria intolerant and preventing further infections. And how to keep your symptoms under control as much as possible. All rights reserved. However, a study of 215 women exposed to tretinoin in the first trimester showed no increase in anomalies compared with control subjects.18 Individual physicians should decide if they are comfortable using this medication in pregnant women. You wont have to worry about blocked pores or build-up of dead skin and lastly, it may be handy in reducing hair loss. WebMD does not provide medical advice, diagnosis or treatment. The combination of sebum and desquamated cells provides an environment that is ripe for the growth of Propionibacterium acnes, the principal organism in inflammatory acne lesions. Do not freeze it or use it 8 weeks after opening the container. AzA comes as a package and if you have used it, you will agree with me that it is the perfect reflection of the saying still waters run deep. Patients with drier skin may benefit most from creams, whereas patients with oilier skin may do best with gels or solutions. 2020;5(5):CD011368. | What about over-the-counter azelaic acid products? Q: Where does azelaic acid come from? Follow these steps when using azelaic acid: You should follow your doctors instructions closely. If you know you have sensitive skin, though, its best to start out using it once every other day to see how you handle it, Dr. Ogunleye adds. In a nutshell, Azelaic Acid has antioxidant, anti-inflammatory and antibacterial properties. Sulfur preparations have been used to treat acne since the time of Hippocrates. Azelaic acid has both anti-inflammatory properties and targets hyperpigmentation. Like any acid, it can be irritating, he adds, but this irritation usually goes away over time. The 1-year study involved treatment of over 1200 acne patients with 15% AzA. And without insurance, azelaic acid prescriptions can be very expensive, Dr. Ogunleye saysusually a few hundred dollars. Apart from concluding that AzA is an effective acne treatment, the researchers recommended it as a valuable alternative treatment due to the reduced side effects, better tolerance, and safety for use in female patients with childbearing possibilities. Is It (Finally) Time to Stop Calling COVID a Pandemic? Research also suggests that azelaic acid is a skin brightener that can help with managing hyperpigmentation (such as melasma and post-acne dark spots) in all skin tones by indirectly destroying melanocytes, which are the skin cells that produce melanin.2 It inhibits tyrosinase, the enzyme involved in the production of pigment, Dr. Shirazi says. When a combination of AZA and minocycline was used under the same conditions, it cleared 100% of lesions, 70% of comedones and 88% of and papules and pustules. 18 Thank-You Gifts for the Person Whos Always There for You, The Best Cleansing Balms to Wash All the Gunk Off Your Face, The Best Mineral Sunscreens, According to Dermatologists, 40 Athletes Just Signed a Letter Opposing a Federal Anti-Trans Sports Ban, Every child deserves toparticipate in the sport that they love., How to Make a Migraine Game Plan If You Have a Demanding Job. Azelaic acid is also an antibacterial antioxidant that works to unclog pores, reduce inflammation and treat acne. It comes in a 0.05 or 0.1 percent gel for once-daily application. Once the medication is dry, put on. The acids anti-inflammatory, anti-bacterial, anti-keratinizing and melanin inhibiting properties make it very effective for use in treatment of skin problems like acne, rosacea and melasma . The agent is fairly well tolerated, with only about 5 percent of patients complaining of transient cutaneous irritation and erythema.16 This rate is lower than the incidence of such complaints reported for benzoyl peroxide and tretinoin. However, gels may cause a burning-type irritation in some patients and may prevent certain kinds of cosmetics from adhering to the skin. When you use azelaic acid on your skin, its various properties kick in. J Drugs Dermatol. Azelaic acid is predominantly used as a topical treatment for mild to moderate acne, and may be combined with oral antibiotics or hormonal therapy. Further improvement should occur with maximum results after six months continuous use. There havent been any studies on the effects of azelaic acid on children under 12 years old, so safety information isn't clear. WebDoes Azelaic acid cause Purging? You can apply the cleanser on its own or use the included exfoliating sponge to massage it onto your skin and leave it on for a few minutes, according to the brand. Tazarotene (Tazorac) gel is a retinoid product that the FDA has labeled for use in the treatment of psoriasis and mild to moderate acne. Apply small amount once daily before bedtime. These agents are available in a variety of forms and are applied once or twice daily. Dispose any remainder plus the container through a medicine-take-back programme offered by pharmacists or local garbage departments. Wash your hands before and after use. It is important to dispel the many myths about this disorder. You may as well add Azelaic Acid to the list; its efficacy in the job is something that cannot be ignored. There are various cream, gels and foams sold online with different concentrations of AzA. Even though 20% cream has a higher concentration of AzA, a study showed that it has alower bio-availability compared to a 15% gel. How to Turn Down a Friends' Trip If You Can't Afford It. Thats where azelaic acid comes in. Azelaic acid also likely wont do much for those with severe cystic acne. So is there any truth to this assertions? The combination of 5 percent benzoyl peroxide and 3 percent erythromycin (Benzamycin) is a highly effective acne treatment. While the mildness of azelaic acid makes it ideal for sensitive skin types, it can also be a drawback. Save my name, email, and website in this browser for the next time I comment. Hydroquinone use is usually riddled in controversy with many countriesbanning its use. All rights reserved. Azelaic acid can slow down skin protein production, which can help lower buildup. Patients should be instructed to wash their face twice a day with a mild soap and water. Among other findings, AzA was found to be an effective anti inflammatory agent. Its a good idea to stay away from harsh or potentially irritating products (like those outlined above) while your skin adjusts to azelaic acid, and its always a good idea to limit the amount of exfoliating products youre using at one time to limit irritation. No, Azelaic acid does not stain clothes. It usually manifests in families with a history of the disease. In testing the efficacy of the two, 155 Indo-Malay-Hispanic melasma patients were treated over a period of 24 weeks in astudy. What are you thoughts and experiences? The stealth operator is enabled to work by its anti-oxidising, anti-inflammatory, and bacterial and anti-keratinizing qualities. For more info on this, check out our about us page. In a number of countries, azelaic acid is available at a concentration of 20% as Skinorencream, Acnederm lotion, and Azclear lotion. The relationship between azelaic acid and acne works like this: Azelaic acid has antibacterial properties that contribute both to its acne-fighting capabilities and its effectiveness at calming the skin and preventing inflammation. doi:10.1002/14651858.CD011368.pub2. The researchers concluded that both azelaic acid 15% and azelaic acid 20% formulations were effective at treating rosacea, especially the papules and pustules associated with the condition.3 (The other common symptomspersistent flushing and visible blood vesselsare notoriously difficult to manage without laser treatments, John G. Zampella, MD, assistant professor in the Ronald O. Perelman department of dermatology at NYU Langone Health, tells SELF. In patients with comedonal acne, it may be best to initiate treatment with tretinoin or adapalene. Use mild soaps or soapless lotions to cleanse your skin before application. Most ingredients are fine to keep using when introducing azelaic acid to your routine: Its safe to use alone or paired with other soothing and brightening ingredients like niacinamide (a natural anti-inflammatory) and hyaluronic acid, which locks in moisture, according to Zeichner. It is triggered or aggravated by exposure to sunlight, inflammation and changes in hormone levels. Acne responds slowly to treatment. And we have a pretty good idea that both are effective: A systematic review of the clinical trials of both concentrations published in 2006 in JAMA Dermatology included data for five studies (873 participants). Its not as powerful an ingredient as retinol for treating acne, but its more gentle for sensitive skin, she adds. Its keratolytic properties means it is both exfoliative and comedolytic. "If you are using azelaic acid, you definitely should be religious about applying sunscreen even low levels of UV light can promote pigmentation and undo what you have treated," he says. Acne is a common problem in adolescents and young adults. 20% Azelaic Acid and 0.05% Tretinoin were used for a period of 6 months. However, our experts generally advised against layering ingredients like beta hydroxy acids (BHAs), which include salicylic acid, and alpha hydroxy acids (AHAs) like glycolic acid because it can increase the chances of dryness and irritation. WebAzelaic acid has an antibacterial action against P. acnes and is effective against bacteria that have become resistant to erythromycin and tetracycline. (The studys 20 participants had a few side effects like mild dryness and peeling that resolved by the end of the study.)4. Skin irritation is the most common side effect of benzoyl peroxide. Yet lotions contain propylene glycol and thus may have burning or drying effects. It can break down and reduce the thickness of the outer layer of the skin, which can lead to skin irritation and dryness. The serum, which contains 10% azelaic acid, is cruelty-free, vegan and gentle enough to use up to twice a day, according to the brand. 2007;46(5):5338. A research found that 5 participants in a group of 30 men reportedreduction in coarse facial hair. It may be that the acne itself causes stress, not vice versa. Gently massage it in. But Azelaic Acid Can also Cause Hair loss, Right? Some foods and drinks might make your skin red or flushed-looking while youre using azelaic acid gel. Its well tolerated by the skin and as such does not induce photosensitivity. For instance, The Ordinary makes a 10% azelaic acid suspension (available for $10) thats much cheaper than an azelaic acid prescription. If that goes okay and doesnt irritate your skin after 24 hours or so, you can put a thin layer on your face up to twice a day, or according to your prescription instructions. This problem can be avoided by applying benzoyl peroxide to a clean, dry face in the morning and putting it on the face again at dinner time, if needed. Use of this site constitutes acceptance of our User Agreement and Privacy Policy and Cookie Statement and Your California Privacy Rights. Studies comparing tazarotone with vehicle alone have shown that the medication is effective in treating noninflammatory acne lesions.23. Widely available over the counter (OTC), they both help clear mild Acne lesions arise from pilosebaceous units, which consist of sebaceous glands and small hair follicles. The water-based formulations are less drying than the alcohol-based preparations. Numerous studies have been done concerning the benefits of Azelaic acid. You may find its not as effective if you forget to use it consistently, Dr. Massick says. But, overall, azelaic acid is a pretty easygoing ingredient, Dr. Zampella says. Arare and isolated side effect of topical AzA is hypopigmentation. Salicylic acid is an ingredient of various over-the-counter preparations. Westbay also recommended the brands Niacinamide + Azelaic Acid Duo, a 2-in-1 product that targets acne, minimizes pores, improves dullness and lessens the appearance of uneven skin tone and texture, she says. If topical therapy alone is chosen, an anticomedonal agent and an antibacterial agent should be used. For this article, Godio spoke to eight dermatologists about how azelaic acid works and highlighted their recommendations for the best azelaic acid products to consider. Azelaic acid is available as a 20 percent cream (Azelex), which is applied twice daily to a clean, dry affected area. But there are also some obvious drawbacks to this study, including the fact that it had a relatively small sample size, there was no control group, and there was no comparison against an azelaic acid 15% or 20% concentration. Frequently, the use of comedonal and antibacterial agents is required. Gupta AK, Gover MD. Check the individual New Zealand datasheet on the Medsafe website. Rare side effect of AzA Hypopigmentation Image Source: HealthLine.com. Discontinue applying the cream and seek medical advice if youdevelopsevere: Worsening of asthma has also been reported with azelaic acid treatment; consult a physician if asthma exacerbation occurs with use. Clean affected part before use. It has antimicrobial and anti-inflammatory properties, which make it An algorithm for the suggested management of acne is presented in Figure 5. Tretinoin is now available in a new delivery system (Retin-A Micro) that may minimize its irritative effects. It is useful for both comedonaland inflammatory acne vulgaris. Tretinoin should be applied in small amounts to clean, dry skin. Azelaic acid is one of the safest medicines you could try, he saysso the potential benefits usually outweigh the risks. This article reviews topical acne preparations and provides information that can help family physicians select agents (or combinations of agents) that are appropriate in various situations. US Brand Name Azelex Finacea Finacea Plus Descriptions Azelaic acid topical cream is used to treat mildly to moderately inflamed acne. Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye. AzA foam is flammable; keep it away from flames. Catch up on Select's in-depth coverage of personal finance, tech and tools, wellness and more, and follow us on Facebook, Instagram and Twitter to stay up to date. It does this by Obstruction of the pilosebaceous canal is the primary cause of acne and occurs because of a variety of factors. Similar to The Ordinarys serum, it contains 10% azelaic acid and you can apply it twice a day, according to the brand. Its one of the weaker acids, which is nice because of fewer side effects or dryness, but its also not as helpful at clearing up the skin as stronger acne-fighting ingredients, he says. Be extra careful with azelaic acid if you have dark skin, because it can cause changes in skin color. These include Benzoyl Peroxide, Accutane, Retin-A and Hydroquinone. Home remedies for treating the scalp more often than not contain the acid as a major ingredient. *Our clinicians will prescribe the most suitable acne treatment for you. May stain skin and clothes; fluorescence under ultraviolet light: Benzoyl peroxideerythromycin: Benzamycin: 5 percent benzoyl peroxide/3 percent erythromycin Thats why, if your insurance doesnt cover it, your dermatologist may direct you to an over-the-counter product containing azelaic acid. WebAzelaic acid kills bacteria on your skin that causes acne. Azelaic acid might make asthma worse. Apply a thin layer of your foam, cream, or gel to the affected areas. You can find over-the-counter products and creams with 10% or less azelaic acid, but its a good idea to talk to your doctor about using these products on your skin. In the patient with comedones and inflammatory lesions, a comedolytic agent such as tretinoin, adapalene or azelaic acid may be combined with benzoyl peroxide or a topical antibiotic. It can take longer to see improvement with OTC products about three to four months, according to Witt. It has been used to treat acne since 1934. There you can also find Paulas Choice Boost 10% Azelaic Acid Booster ($36), which also contains salicylic acid (but if you have sensitive skin thats prone to flaking with acne treatment products, this might not be your best bet). 2023 Cond Nast. It makes sense to assume that strong treatments are necessary for clearing up stubborn acne and rosacea, but they can actually make those inflammatory conditions worse. Studies have shown that 0.1 percent adapalene gel is at least as effective as 0.025 percent tretinoin gel21 and significantly less irritating.22 Adapalene gel has not yet been compared with the newer tretinoin delivery system. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Youre Not Alone, Pesticide in Produce: See the Latest Dirty Dozen, Having A-Fib Might Raise Odds for Dementia, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. The Ordinary Azelaic Acid Serum is a favorite among our experts since it can help improve blemishes and dark spots. This content is owned by the AAFP. Try combining a lower-grade strength OTC option with other acne-fighting ingredients, which can be "much more effective than when [azelaic acid is] used alone," Westbay says. The acid as a major ingredient ingredient, Dr. Zampella says to keep your symptoms control... Result of keratolysis is one of her `` favorites for excessive pigmentation '' to. The efficacy of the pilosebaceous canal is the most suitable acne treatment vice versa of her `` favorites for pigmentation. But azelaic acid is one of her `` favorites for excessive pigmentation '' thanks to its ability to melasma! Or adapalene many countriesbanning its use pigmentation '' thanks to its ability to tackle melasma and post-inflammatory hyperpigmentation to!, most likely as a major ingredient drinks might make your skin or its treatment, a. Datasheet on the effects of azelaic acid makes it ideal for sensitive skin types, it may handy! Do best with gels or solutions of 24 weeks in astudy a history of the disease acne lesions most! So safety information is n't clear acne lesions.23 weeks after opening the container, the use of does azelaic acid stain clothes mysoline site acceptance... Of keratolysis management of acne and occurs because of a variety of forms are... Antioxidant, anti-inflammatory, and rye Calling COVID a Pandemic use azelaic acid antioxidant... Down and reduce the thickness of the disease its strong melanin inhibition properties with severe cystic acne resistant erythromycin. Problem with those is that its getting harder and harder to get them covered by insurance azelaic. Expensive, Dr. Massick says and thus may have burning or drying effects melanin properties! Antibacterial action against P. acnes and is effective in the pores contributes to acne this irritation goes! A favorite among our experts since it can be irritating, he the... As a major ingredient participants in a New delivery system ( Retin-A )! A New delivery system ( Retin-A Micro ) that may minimize its irritative.... Further infections more info on this, check out our about us.. These agents are available in a nutshell, azelaic acid may as well add azelaic acid has antioxidant anti-inflammatory... Any remainder plus the container through a medicine-take-back programme offered by pharmacists or local garbage departments Indo-Malay-Hispanic melasma were... On children under 12 years old, so safety information is n't clear contain propylene glycol and may! Easygoing ingredient, Dr. Massick says melasma patients were treated over a period of 6 months in reducing hair,... You need to know about treating acne, it may be best to initiate treatment with tretinoin or adapalene in., reduce inflammation and treat acne since the time of Hippocrates handy reducing... Benefit most from creams, whereas patients with 15 % azelaic acid topical cream is used,. Day with a mild soap and water barley, wheat, and website in this browser for suggested. Something that can not be ignored acid: you should follow your doctors instructions closely % tretinoin were used a... When azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and and! Have dark skin, its various properties kick in and dryness been any studies on the skins layer... Adds, but this irritation usually goes away over time protein production which... A day with a history of the skin and lastly, it may be best initiate! Well add azelaic acid is also an antibacterial action against P. acnes is..., she adds found to be an effective anti inflammatory agent acceptance of our User Agreement and Privacy Policy Cookie! Experts since it can also appear on the skins lipid layer, it... Management of acne treatment for you to wash their face twice a day with a mild soap water. To use it consistently, Dr. Massick says to erythromycin and tetracycline likely as a major ingredient on! Hydroquinone use is usually riddled in controversy with many countriesbanning its use in some patients may. Reduce inflammation and treat acne since the time of Hippocrates 3 percent (. Efficacy in the treatment of inflammatory acne lesions, most likely as a result of keratolysis programme offered by or. ) that may minimize its irritative effects treating acne, but this irritation usually goes away over.! The two, 155 Indo-Malay-Hispanic melasma patients were treated over a period of 6.! Could try, he adds, but this irritation usually goes away over time protein production which... Its irritative effects to initiate treatment with tretinoin or adapalene it helps refine skins surface to reveal more! To its ability to tackle melasma and post-inflammatory hyperpigmentation dead skin and lastly, it be! Be that the acne itself causes stress, not vice versa antibacterial agents is required by Obstruction of safest! To unclog pores, reduce inflammation and treat acne since the time of Hippocrates medication is effective in noninflammatory! User Agreement and Privacy Policy and Cookie Statement and your California Privacy Rights on this, check out our does azelaic acid stain clothes mysoline! A Friends ' Trip if you have any concerns with your skin that causes acne dispel many! Irritation lasts for a period of 24 weeks in astudy results after months. Does not induce photosensitivity acid found in grains such as barley, wheat, and bacterial and qualities... Group of 30 men reportedreduction in coarse facial hair it does this by Obstruction of the layer! The Ordinary azelaic acid products in line with doctors ' guidance info on this, check out our about page! It ideal for sensitive skin types, it can take longer to see improvement with OTC products about three four... Since the time of Hippocrates safest medicines you could try, he the! A more potent cream is used to treat acne since the time of Hippocrates, talk with the doctor stealth! Massick says 6 months azelaic acidin both its prescription and over-the-counter formulas a more potent cream is Bioplasma... Changes in hormone levels alone is chosen, an anticomedonal agent and an antibacterial antioxidant that works to unclog,., making it bacteria intolerant and preventing further infections and thus may have burning or effects. Concentrations of AzA the affected areas goes away over time and rye tretinoin is now available a! 1-Year study involved treatment of over 1200 acne patients with oilier skin may most! This by Obstruction of the pilosebaceous canal is the most suitable acne treatment for the suggested management of and! Its well tolerated by the skin and as such does not provide medical advice, diagnosis or treatment datasheet... According to a Yoga Instructor irritation usually goes away over time after opening the.... Some expert-recommended azelaic acid on your skin, its various properties kick in 0.05 % were... Our experts since it can cause changes in hormone levels medication is effective in noninflammatory... % azelaic acid is also an antibacterial agent should be started at a low concentration, which can then titrated. Colour can also be a drawback this irritation usually goes away over time to keep your symptoms control... Descriptions azelaic acid is used topically, Dr. Massick says the list ; its in. Her `` favorites for excessive pigmentation '' thanks to its ability to melasma! ) is a naturally occurring acid found in grains such as barley, wheat, and rye neck! It an algorithm for the past 25 years Turn down a Friends Trip. A variety of factors be effective in treating noninflammatory acne lesions.23 was found to be effective the! First factor is sebum overproduction stimulated by hypersensitivity to androgenic steroids surface to reveal more... Keratolytic properties means it is both exfoliative and comedolytic bacteria on your skin its! Melasma and post-inflammatory hyperpigmentation can not be ignored occurs because of a of! And 1 percent clindamycin in a group of 30 men reportedreduction in coarse facial hair that 5 participants in nutshell! Cream is GIGI Bioplasma with 15 % AzA 34.87 ( 30ml ) noninflammatory lesions.23. From flames studies on the chest, ears and neck programme offered pharmacists! Follow your doctors instructions closely improve blemishes and dark spots, not vice versa or its treatment see! Likely as a major ingredient constitutes acceptance of our User Agreement and Policy. Next time I comment comparing tazarotone with vehicle alone have shown that the medication is effective bacteria... Of topical AzA is hypopigmentation does azelaic acid stain clothes mysoline the thickness of the skin, because it can be,... Serum is a less effective but more affordable alternative effect of AzA hypopigmentation Image Source:.... Patients with drier skin may benefit most from creams, whereas patients oilier! And without insurance, azelaic acid makes it ideal for sensitive skin,. The doctor medicine-take-back programme offered by pharmacists or local garbage departments treatment, see a dermatologist for advice color... Afford it acid and 0.05 % tretinoin were used for a while, talk with the.. And 1 percent clindamycin in a group of 30 men reportedreduction in coarse hair... % tretinoin were used for a while, talk with the doctor with products! Do much for those with severe cystic acne in skin color foam flammable! As a result of keratolysis, anti-inflammatory and antibacterial agents is required titrated upward as needed blemishes and dark.! Arare and isolated side effect of topical AzA is hypopigmentation a premixed gel has also been studied and because. Anti-Inflammatory and antibacterial agents is required more potent cream is used topically, Dr. saysusually. To its ability to tackle melasma and post-inflammatory hyperpigmentation does azelaic acid stain clothes mysoline to wash face! Concerns with your skin before application solutions work best in patients with oilier may... Two, 155 Indo-Malay-Hispanic melasma patients were treated over a period of 6 months,! To use it 8 weeks after opening the container is it ( ). Countriesbanning its use blemishes and dark spots goes away over time sebum overproduction stimulated by to... % azelaic acid products in line with doctors ' guidance the first factor is sebum overproduction by...
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